top of page
Search

Worms/Nematodes in Humans



Sharp interest in it arose after a lot of functional doctors wanted some capsules as in the west to control the same and have got a decent amount of indents.


What fascinated me:


1. Over 2 billion humans were impacted (out of nearly 7 plus billion humans) most of them in developing poor countries including India.

2. Most of the currently traded drugs essentially 4 ways are getting ineffective as these worms or nematodes have already become drug-resistant and for the last 40 years nothing new has come and nothing new is on the drawing board.

3. All drugs started from veterinary medicine to human medicine.



Parasitic nematodes in humans fall into two broad categories:

  1. Intestinal nematodes

  2. Tissue (blood) nematodes


The distinction between these two categories is based on where the adult stage mainly spends its time (in the intestinal lumen or in body tissues). Intestinal parasitic nematodes, which are the most common and persistent parasitic nematodes in humans, infact approximately two billion people worldwide, especially in developing countries. These intestinal parasitic nematodes mainly include Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Enterobius vermicularis and Capillaria philippinensis. The first four species are the most widespread and are normally grouped together as soil-transmitted helminthes, since they have a similar life cycle. The adults live in the human intestine and produce eggs, which are shed with feces and embryonate in the soil.


These parasite infections can cause detrimental effects on human growth, nutrition, cognition, school performance, work productivity, and pregnancy, which may severely impair the quality of life. The majority of intestinal parasitic infections occur in children. A thorough meta-analysis demonstrated that deworming children results in statistically significant improvements in almost all primary outcome measures (height, weight, triceps skin fold, and mid-upper arm circumference) and in all secondary outcome measures (e.g., height-for-age, weight-for-age, etc.). Moreover, the infections also indirectly cause a considerable disease burden via impairment of the immune system, leading to increased susceptibility to malaria, HIV/AIDS, and tuberculosis.


The problem:


“In the absence of vaccines for human intestinal nematodes, the treatment of nematode infections at present mainly relies on chemotherapy. Despite the severe impact on health caused by intestinal nematodes and their high prevalence in humans, the arsenal of anthelmintic drugs is small. Four main anthelmintic drugs are used for treating human intestinal nematodes: pyrantel pamoate, albendazole, mebendazole, and levamisole. “

And all this led to an interest in finding something from the herbal world which has a history of thousands of years of use. There are many medicinal-plant-derived drugs that have been introduced to the market worldwide, such as artemether, galantamine, and tiotropium. Notably, the discovery of artemisinin (an antimalarial drug) from Artemisia annua, which is used in traditional medicine across the globe, was awarded the Nobel Prize in Physiology or Medicine in 2015.

Currently, around 15 active ingredients from the herbal world and several essential oils have shown promising results.


Conclusions:


There is no permanent or effective agent for this --- a lot of it has to do with soil hygiene ---which will not change in decades to come. What is sold in the market is ineffective and has several side effects. Thus any protocol needs to be slow working, regular working.

Current herbal treatment consists of several capsules in the monthly cycle and we have been discussing with doctors and have reached a broad consensus that we consolidate 3 capsules in 1 capsule by using extracts that reduce complexity and costs.


We already have a monthly mandate of 300 bottles of 100 capsules and we have to plan the cycle in our new unit and hope to start delivering from Feb. This note is to explore interests within our members because the larger the quantity lower will be the price.
19 views0 comments

Kommentare


bottom of page